Codeine and promethazine is a mix drugs employed to deal with chilly or allergy indicators which include runny nose, sneezing, and cough.

Although it can help Lots of individuals, this medication features a chance for abuse and should occasionally induce addiction. This chance may very well be bigger if you have a material use condition (including overuse of or addiction to prescription drugs/Alcoholic beverages).

To help you protect against withdrawal, your physician may well lessen your dose gradually. Withdrawal is more most likely Should you have made use of this medication for a long time (more than a few weeks) or in large doses. Explain to your health practitioner or pharmacist at once When you've got withdrawal.

Get health care help instantly when you observe any of the following: slow/shallow respiration, critical drowsiness/problems waking up, confusion.

Generally use an exact milliliter measuring unit when administering Promethazine with Codeine Oral Remedy to make sure that the dose is measured and administered precisely. A household teaspoon is just not an exact measuring system and may lead to overdosage [see Warnings and Safeguards ( five.seven)]. For prescriptions in which a measuring machine isn't presented, a pharmacist can offer an correct measuring gadget and can offer instructions for measuring the right dose. Tend not to overfill.

The concomitant utilization of Promethazine with Codeine Oral Option with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may perhaps lead to lessen codeine amounts, larger norcodeine degrees, and fewer metabolism by using 2D6 with resultant reduce morphine degrees. This can be connected with a lessen in efficacy, and in certain clients, may lead to symptoms and signs of opioid withdrawal.

No formal reports have already been carried out in individuals with hepatic impairment Hence the pharmacokinetics of Promethazine with Codeine Oral Solution In this particular individual inhabitants are unknown.

Promethazine with Codeine Oral Alternative needs to be applied with caution in sufferers with critical impairment of renal function, and individuals ought to be monitored carefully for respiratory melancholy, sedation, and hypotension.

The respiratory depression includes a discount in the responsiveness in the brain stem respiratory centers to both of those raises in carbon dioxide stress and also to electrical stimulation.

Codeine: Dosage of codeine Really should not be Enhanced if cough fails to respond; an unresponsive cough need to be reevaluated in 5 times or sooner for achievable underlying pathology, which include international physique or reduced respiratory tract ailment.

A likely fatal symptom elaborate at times generally known as Neuroleptic Malignant Syndrome (NMS) is reported in association with promethazine HCl on your own or in combination with antipsychotic medication.

Treatment of Overdose Procedure of overdosage is driven by the general medical presentation, and is made up of discontinuation of Promethazine with Codeine Oral Resolution collectively with institution of appropriate therapy. Give Principal awareness for the reestablishment of ample respiratory exchange through provision of the patent and protected airway as well as establishment of assisted or controlled air flow.

“Physician buying” (viewing check here many prescribers to obtain added prescriptions) is prevalent amid drug abusers and people suffering from untreated habit. Preoccupation with acquiring adequate agony reduction is often correct habits in a client with lousy suffering Management.

are pregnant or strategy to become pregnant. PROMETHAZINE WITH CODEINE ORAL SOLUTION can damage your unborn newborn. See “What's A very powerful details I should really know about PROMETHAZINE WITH CODEINE ORAL SOLUTION?” are breastfeeding or plan to breastfeed. Codeine passes into your breast milk and may cause critical Unintended effects within your infant such as increased sleepiness, respiration challenges (respiratory depression), and Loss of life. It's not acknowledged if promethazine can move into your breast milk.